Biological actions of nitroarenes in short-term tests on Salmonella, cultured mammalian cells and cultured human tracheal tissues: possible basis for regulatory control.

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Biological actions of nitroarenes in short-term tests on Salmonella, cultured mammalian cells and cultured human tracheal tissues: possible basis for regulatory control.

Pure synthetic nitropyrene compounds were subjected to a mutation test using Salmonella typhimurium TA 98 and TA 100 with and without S9 mix, a metabolic activation system. Dinitropyrenes were highly mutagenic. Among them, 1,8-dinitropyrene was the most potent mutagen, producing 940,000 revertants of TA 98/micrograms. 1,3,6-Trinitropyrene and 1,3,6,8-tetranitropyrene were also highly mutagenic,...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1983

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.8347171